The 4th generation combination antigen/antibody test is the latest and most accurate HIV test out there, with a sensitivity of 99.7% and a specificity of 99.9%, according to the World Health Organization. An HIV test can detect the presence of HIV in the blood up to 4 weeks after exposure---but keep in mind that this doesn't mean you're necessarily infected with HIV. There's no way to be 100% sure of an HIV diagnosis without taking another test at 3 months post-exposure (this means having your first one at 28 days after exposure). It's important not to rely on just one result---even if it came back negative---because there are many factors that determine how long it takes before someone tests positive for HIV.
The 4th generation combination antigen/antibody test is the latest and most accurate HIV test out there, with a sensitivity of 99.7% and a specificity of 99.9%, according to the World Health Organization. This means that for every 1000 people in whom you test for antibodies for HIV at this stage after risk, only one person will have false-positive results. According to US National Library of Medicine National Institutes of Health (NIH), this is also referred to as "the gold standard" due to its high accuracy rate.
That said, it's important not to panic if your result comes back negative four weeks after a potential exposure; only 1 in 100 people infected with the virus will produce enough antibodies within 14 days of getting infected; these antibodies usually appear between 10–12 days after infection occurs, though they can take up to 3 months before they're detectable by even the most sensitive tests available today (such as those used by doctors).
The answer to this question is that there's no way to be 100% sure of an HIV diagnosis without taking another test at 3 months post-exposure. If you were worried about the accuracy of your 4th generation test, then you would have needed to wait for it to come back negative and then take a second test around 3 months later (around 120 days).
Not everyone will want to wait, but if you're feeling anxious about whether or not your risk was worth it in the long run, consider taking another test just so that you can rest easy knowing for sure.
If you took a 4th generation HIV test at the three-month mark, that does not mean you're in the clear. It's crucial to take a follow-up test at exactly 90 days AFTER you were exposed (not when your result came back), and then again every six months after that for as long as you remain sexually active. You can't rely on early results like those from a 4th generation test—you need to wait until they're conclusive, even if this means waiting longer than four weeks.
Though you can't rely on a 4th generation test taken at 4 weeks post-exposure, you can trust a repeated test at 90 days post-exposure. This is because the sensitivity of the fourth generation test is 99.7% and its specificity is 99.9%, which means that it has an extremely high accuracy rate, usually over 99%.
The fourth generation HIV test will detect HIV in the blood up to 4 weeks after exposure. However, since this time period can be longer for certain individuals (some people who became infected with HIV may not produce enough antibodies for it to be detected by a blood test until as many as 10 weeks), it's important to follow up with another HIV test at 90 days after your risk based on when your last possible exposure was rather than relying solely on one positive result from an earlier point in time
Overall, the 4th generation HIV test is a great way to test for HIV. It's highly sensitive and specific for the virus, so you can rest assured that if your test is positive then it's probably true. However, due to the potential window period after exposure where it will be negative but still give a positive result at 90 days post-exposure, we recommend taking another test 3 months after being exposed as well as reviewing other possible factors influencing this timing. As always: if there are any questions about whether or not an individual should get tested for HIV please contact their healthcare provider who can help determine whether testing is appropriate and offer counseling services if needed!